Antidiabetic activity, polyphenols-based characterization and molecular interaction of extract of un-ripe pods of Vinca rosea cv. Pink

The study aimed to investigate extracts of un-ripe pods Vinca rosea cv. Pink for antidiabetic activity and polyphenol-based characterization using HPLC. Moreover, the molecular interaction identified markers with targets was explored molecular-docking software. Different were prepared investigated models such as glucose uptake by yeast cells, alpha amylase inhibition haemoglobin-glycosylation assays. most active extract characterized HPLC chlorogenic, caffeic ferrulic acids an analytical markers. taken ligands docking pancreatic α-amylase, glycogen phosphorelase hexokinase-Ι 1-Click Docking Mcule Software, finding hydrogen-bonding affinities UCSF Chimera 1.12. Methanol showed higher 37.77, 71.16 53.52% α-amylase assay, increase in glucose-uptake Hb-glycosylation respectively. found contain 0.25 mg/g chlorogenic 0.11 acids. These be good diabetes related targets. results indicate that methanol has activity, which may assigned compounds used pharmacological standardize extracts.